Probuphine Implant

Probuphine Implant for Opiate Addiction

Tentatively set for January 2017, we will begin offering our newest medication-assisted opioid addiction treatment — the Probuphine Implant. The Probuphine Implant, which is a subdermal implant that steadily administers buprenorphine over a 6-month period, is the first of its kind available today. In comparison to customary opioid addiction treatments, Probuphine dramatically reduces patient concerns in regards to taking the medicine incorrectly and/or lack of pharmacy accessibility, as well as medications getting lost or stolen.

In comparison to traditional medications available today where the patient has to remember how much medication to administer and at what specific times throughout the day, the implant allows the initial prescribed dose to be safely and continuously released throughout the body. Some patients have difficulty with the traditional method of taking the sublingual dose, which has to be done in a certain way or it won’t absorb properly. Furthermore, accidentally missing a dose could trigger a relapse.

Freedom to focus attention from taking the medication daily to having the option to devote that allotted mindfulness to other daily activities makes this one of the most revolutionary opioid addiction options available today.


Do I have to go to the hospital to have the Probuphine implanted?

No, you do not. This is a relatively simple surgical procedure that can be done in the office, without anesthesia. A small dose of local anesthetic may be administered to numb the skin for the patient’s convenience.

The medication is contained within a small rod that is inserted under the skin and subsequently released in a time-based method by utilizing proprietary, continuous drug delivery technology. As a result, this method prevents both withdrawal and euphoria, and aids in the cessation of physical craving for opioids. The implant dispenses medication for up to 6 months

Can all doctors prescribe Probuphine and perform the insertion procedure?

Administering Probuphine requires specific training because it must be surgically inserted and removed. Only a health care provider who has completed the training and become certified through a restricted program called the Probuphine Risk Evaluation and Mitigation Strategy (REMS) program should insert and remove the implants

Are there any side effects?

The safety of Probuphine Implants is well-supported by FDA clinical trials, and the occurrence of side effects was very uncommon. Possible side effects may include implant-site reactions (pain, itching, redness, and swelling), headache, nausea, constipation, abdominal pain, fatigue, weakness, and fever.

How much does it cost?

The price of cost per treatment varies directly with the compatibility of the patient’s insurance. Please check with your provider to see if coverage is offered.

Does it actually work?

According to the FDA, “sixty-three percent of Probuphine-treated patients had no evidence of illicit opioid use throughout the six months of treatment – similar to the 64 percent of those who responded to sublingual (under the tongue) buprenorphine alone.”

To read more, visit FDA approves first buprenorphine implant for treatment of opioid dependence.

We also offer Medication Assisted Treatment (MAT) for Addiction and Medication Assisted Management (MAT) for Opioid Addiction. Learn more about these treatments here.